Terms & Properties

Preferred Name:  Pemetrexed

Definition:  A synthetic pyrimidine-based antifolate. Pemetrexed binds to and inhibits the enzyme thymidylate synthase (TS), which catalyses the methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP), an essential precursor in DNA synthesis.

Display Name:  Pemetrexed

Label:  Pemetrexed

NCI Thesaurus Code:  C61614 (Search for linked caDSR metadata)   (search value sets)

NCI Metathesaurus Link:  C0210657  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)

L-Glutamic Acid, N-(4-(2-(2-Amino-4,7-dihydro-4-oxo-1H-pyrrolo(2,3-d)pyrimidin-5-yl)ethyl)benzoyl)

MTA

Multitargeted Antifolate

Pemetrexed

PEMETREXED

Pemfexy

External Source Codes: 

CAS Registry Number	137281-23-3 (see NLM ChemIDplus info)
FDA UNII Code	04Q9AIZ7NO
ChEBI ID	CHEBI:63616 (see ChEBI info)
UMLS CUI	C0210657

Other Properties:

Name	Value (qualifiers indented underneath)
Chemical_Formula	C20H21N5O6
code	C61614
Contributing_Source	CTRP
Contributing_Source	FDA
Contributing_Source	GDC
Contributing_Source	HemOnc
Legacy Concept Name	Pemetrexed_Base
Maps_To	Pemetrexed
	Target_Terminology: GDC       Relationship_to_Target: Has Synonym       Target_Term_Type: PT       Target_Code: therapeutic_agents
NSC Number	698037
Semantic_Type	Organic Chemical
Semantic_Type	Pharmacologic Substance

Additional Concept Data: 

Defined Fully by Roles: No

URL:https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C61614