Terms & Properties

Preferred Name:  Levofloxacin

Definition:  A broad-spectrum, third-generation fluoroquinolone antibiotic and optically active L-isomer of ofloxacin with antibacterial activity. Levofloxacin diffuses through the bacterial cell wall and acts by inhibiting DNA gyrase (bacterial topoisomerase II), an enzyme required for DNA replication, RNA transcription, and repair of bacterial DNA. Inhibition of DNA gyrase activity leads to blockage of bacterial cell growth.

NCI-GLOSS Definition:  A substance used to treat bacterial infections. It belongs to the family of drugs called quinolone antibiotics.

Display Name:  Levofloxacin

Label:  Levofloxacin

NCI Thesaurus Code:  C1586 (Search for linked caDSR metadata)   (search value sets)

NCI Metathesaurus Link:  C0282386  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)

(S)-9-Fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyrido(1,2,3-de)-1,4-benzoxazine-6-carboxylic Acid Hydrate (2:1)

7H-Pyrido(1,2,3-de)-1,4-benzoxazine-6-carboxylic Acid, 9-Fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-, Hydrate (2:1), (S)-

Levaquin

Levofloxacin

levofloxacin

LEVOFLOXACIN

Levofloxacin Hydrate

Quixin

External Source Codes: 

CAS Registry Number	138199-71-0 (see NLM ChemIDplus info)
NCI Drug Dictionary ID	37941 (see NCI Drug Dictionary info)
FDA UNII Code	6GNT3Y5LMF
PDQ Closed Trial Search ID	37941
PDQ Open Trial Search ID	37941
UMLS CUI	C0282386

Other Properties:

Name	Value (qualifiers indented underneath)
Chemical_Formula	2C18H20FN3O4.H2O
code	C1586
Contributing_Source	CTRP
Contributing_Source	FDA
Contributing_Source	HemOnc
Legacy Concept Name	Levofloxacin
Semantic_Type	Antibiotic
Semantic_Type	Organic Chemical
Semantic_Type	Pharmacologic Substance

Additional Concept Data: 

Defined Fully by Roles: No

URL:https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C1586