Terms & Properties

Preferred Name:  Myeloid Leukemia Associated with Down Syndrome

Definition:  Acute myeloid leukemia or myelodysplastic syndrome occurring in children with Down syndrome. The acute myeloid leukemia is usually an acute megakaryoblastic leukemia, and is associated with GATA1 gene mutation.

NICHD Definition:  Acute myeloid leukemia occurring in children with Down syndrome. During the first 3 years of life, it is usually the megakaryoblastic subtype, and is associated with GATA1 gene mutation. After age 4 this is no longer the case.

Label:  Myeloid Leukemia Associated with Down Syndrome

NCI Thesaurus Code:  C43223 (Search for linked caDSR metadata)   (search value sets)

NCI Metathesaurus Link:  C2825149  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)

Acute Myeloid Leukemia Occurring in Children with Down syndrome

Acute Myeloid Leukemia with GATA1 Mutations

AML Occurring in Children with Down Syndrome

MLDS

Myeloid Leukemia Associated with Down Syndrome

Myeloid leukemia associated with Down Syndrome

External Source Codes: 

UMLS CUI

C2825149

Other Properties:

Name	Value (qualifiers indented underneath)
code	C43223
Contributing_Source	Cellosaurus
Contributing_Source	GDC
Contributing_Source	NICHD
Contributing_Source	PCDC
ICD-O-3_Code	9898/3
Legacy Concept Name	Acute_Myeloid_Leukemia_Transient_Myeloproliferative_Disorder_in_Down_Syndrome
Maps_To	9898/3
	Target_Terminology: GDC       Relationship_to_Target: Related To       Target_Term_Type: PT       Target_Code: morphology
Maps_To	Myeloid leukemia associated with Down Syndrome
	Target_Terminology: GDC       Relationship_to_Target: Has Synonym       Target_Term_Type: PT       Target_Code: primary_diagnosis
Maps_To	Myeloid leukemia associated with Down Syndrome
	Target_Terminology: ICDO3       Target_Terminology_Version: 3.1       Relationship_to_Target: Related To       Target_Term_Type: PT       Target_Code: 9898/3
Maps_To	Myeloid leukemia associated with Down syndrome
	Target_Terminology: ICDO3       Target_Terminology_Version: 3.2       Relationship_to_Target: Related To       Target_Term_Type: PT       Target_Code: 9898/3
Neoplastic_Status	Malignant
Semantic_Type	Neoplastic Process

Additional Concept Data: 

Defined Fully by Roles: Yes

URL:https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C43223