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Version: 16.11d (Release date: 2016-11-28)
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EGFR Inhibitor CO-1686 (Code C99905)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: EGFR Inhibitor CO-1686

Definition: An orally available small molecule, irreversible inhibitor of epidermal growth factor receptor (EGFR) with potential antineoplastic activity. EGFR inhibitor CO-1686 binds to and inhibits mutant forms of EGFR, including T790M, thereby leading to cell death of resistant tumor cells. Compared to other EGFR inhibitors, CO-1686 inhibits T790M, a secondary acquired resistance mutation, as well as other mutant EGFRs and may have therapeutic benefits in tumors with T790M-mediated resistance to other EGFR tyrosine kinase inhibitors. This agent shows minimal activity against wild-type EGFR, hence does not cause certain dose-limiting toxicities.

Display Name: EGFR Inhibitor CO-1686

Label: EGFR Inhibitor CO-1686

NCI Thesaurus Code: C99905 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C3275041  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
CO-1686
EGFR Inhibitor CO-1686
Rociletinib

External Source Codes: 
PDQ Closed Trial Search ID 725346
PDQ Open Trial Search ID 725346 (check for NCI PDQ open clinical trial info)
UMLS CUI C3275041

Other Properties:
Name Value (qualifiers indented underneath)
code C99905
Contributing_Source CTRP
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C99905

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