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Version: 17.12d (Release date: 2017-12-26)
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Rociletinib (Code C99905)

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Terms & Properties

Preferred Name: Rociletinib

Definition: An orally available small molecule, irreversible inhibitor of epidermal growth factor receptor (EGFR) with potential antineoplastic activity. Rociletinib binds to and inhibits mutant forms of EGFR, including T790M, thereby leading to cell death of resistant tumor cells. Compared to other EGFR inhibitors, CO-1686 inhibits T790M, a secondary acquired resistance mutation, as well as other mutant EGFRs and may have therapeutic benefits in tumors with T790M-mediated resistance to other EGFR tyrosine kinase inhibitors. This agent shows minimal activity against wild-type EGFR, hence does not cause certain dose-limiting toxicities.

Display Name: Rociletinib

Label: Rociletinib

NCI Thesaurus Code: C99905 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C4045493  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
CO-1686
N-(3-((2-((4-(4-Acetylpiperazin-1-yl)-2-methoxyphenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)amino)phenyl)prop-2-enamide
Rociletinib
ROCILETINIB

External Source Codes: 
CAS Registry Number 1374640-70-6 (see NLM ChemIDplus info)
FDA UNII Code 72AH61702G
PDQ Closed Trial Search ID 725346
PDQ Open Trial Search ID 725346 (check for NCI PDQ open clinical trial info)
UMLS CUI C4045493

Other Properties:
     Name Value (qualifiers indented underneath)
code C99905
Contributing_Source CTRP
Contributing_Source FDA
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C99905

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