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Version: 17.06d (Release date: 2017-06-26)
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Gallium Ga 68-labeled BNOTA-PRGD2 (Code C99904)

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Terms & Properties

Preferred Name: Gallium Ga 68-labeled BNOTA-PRGD2

Definition: A radiopharmaceutical agent comprised of a pegylated arginine-glycine-aspartic acid dimer (PRGD2) labeled with gallium Ga 68, with potential alphaVbeta3 integrin imaging activity upon positron emission topography (PET) or single photon emission computed tomography (SPECT). This radiopharmaceutical is prepared by conjugating PRGD2 with chelator S-2-(4-isothiocyanatobenzyl)-1,4,7-triazacyclononane-1,4,7-triacetic acid (BNOTA) which is capable of forming a six-coordinate complex with Ga 68. After intravenous administration, gallium Ga 68-labeled BNOTA-PRGD2 binds to alphaVbeta3 integrin on the cell membrane via the cyclic tri-amino acids RGD motif. Upon PET imaging, alphaVbeta3 integrin-expressing tumor cells can be visualized and expression levels can be quantified. Compared to other radiolabeled RGD-containing peptides, this agent shows increased affinity to alphaVbeta3 integrin, enhanced tumor uptake as well as improved pharmacokinetics. alphaVbeta3 integrin is overexpressed on certain tumor cells and tumor endothelial cells while minimally or not expressed on healthy, normal cells and plays a key role in angiogenesis, tumor proliferation and survival.

Label: Gallium Ga 68-labeled BNOTA-PRGD2

NCI Thesaurus Code: C99904 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C3275040  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Gallium Ga 68-labeled BNOTA-PRGD2

External Source Codes: 
PDQ Closed Trial Search ID 725242
PDQ Open Trial Search ID 725242 (check for NCI PDQ open clinical trial info)
UMLS CUI C3275040

Other Properties:
     Name Value (qualifiers indented underneath)
code C99904
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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