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Version: 17.06d (Release date: 2017-06-26)
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HER2 ECD+TM Virus-like Replicon Particles Vaccine AVX901 (Code C99903)

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Terms & Properties

Preferred Name: HER2 ECD+TM Virus-like Replicon Particles Vaccine AVX901

Definition: A cancer vaccine based on virus-like replicon particles (VRP) packaged with an alphaviral vector encoding the extracellular domain (ECD) and transmembrane (TM) regions of the human epidermal growth factor receptor 2 (EGFR2, NEU or HER2), with potential antineoplastic activity. After immunization with HER2 ECD+TM virus-like replicon particles vaccine AVX901, the VRPs infect cells and express HER2 ECD+TM protein that may activate the immune system to elicit a cytotoxic T-lymphocyte (CTL) response against HER2-expressing tumor cells. The alphaviral replicon of this vaccine is an attenuated strain of the Venezuelan equine encephalitis virus (VEEV) in which 3 of the 7 viral genes were substituted with a truncated HER2 gene to create a self-amplifying replicon RNA. HER2, a tyrosine kinase involved in several cell growth signaling pathways, is dysregulated or overexpressed in a wide variety of cancer cell types.

Display Name: HER2 ECD+TM Virus-like Replicon Particles Vaccine AVX901

Label: HER2 ECD+TM Virus-like Replicon Particles Vaccine AVX901

NCI Thesaurus Code: C99903 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL433604  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
AVX901
HER2 ECD+TM Virus-like Replicon Particles Vaccine AVX901
HER2 ECDTM VRP
VRP-HER2 ECDTM

External Source Codes: 
PDQ Closed Trial Search ID 725234
PDQ Open Trial Search ID 725234 (check for NCI PDQ open clinical trial info)
NCI META CUI CL433604

Other Properties:
     Name Value (qualifiers indented underneath)
code C99903
Contributing_Source CTRP
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C99903

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