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Version: 17.06d (Release date: 2017-06-26)
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Allogeneic Dendritic Cell Vaccine COMBIG-DC (Code C99902)

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Terms & Properties

Preferred Name: Allogeneic Dendritic Cell Vaccine COMBIG-DC

Definition: A cancer vaccine consisting of allogeneic, immortalized dendritic cells (DCs) loaded with tumor specific antigens and activated, with potential immunostimulatory and antineoplastic activities. Upon intratumoral administration of the allogeneic dendritic cell vaccine COMBIG-DC, these activated DCs attract natural killer (NK) cells, induce an anti-inflammatory response leading to the induction of NK-cell-mediated tumor cell death. Upon release of tumor associated antigens (TAAs) from the lysed tumor cells, these antigens are taken up by antigen presenting cells which activate the immune system to elicit a potent cytotoxic T-cell (CTL) response against the TAAs, resulting in the death of TAAs-expressing tumor cells.

Label: Allogeneic Dendritic Cell Vaccine COMBIG-DC

NCI Thesaurus Code: C99902 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL433603  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Allogeneic Dendritic Cell Vaccine COMBIG-DC
COMBIG-DC

External Source Codes: 
PDQ Closed Trial Search ID 724859
PDQ Open Trial Search ID 724859 (check for NCI PDQ open clinical trial info)
NCI META CUI CL433603

Other Properties:
     Name Value (qualifiers indented underneath)
code C99902
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C99902

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