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Version: 16.11d (Release date: 2016-11-28)
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Amonafide Dihydrochloride (Code C999)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Amonafide Dihydrochloride

Definition: The dihydrochloride salt of amonafide, an imide derivative of naphthalic acid. Amonafide intercalates into DNA and inhibits topoisomerase II, resulting in protein-associated strand breaks and impaired DNA and RNA synthesis.

NCI-GLOSS Definition: A substance that is being studied in the treatment of cancer. It belongs to the families of drugs called topoisomerase inhibitors and intercalating agents.

Label: Amonafide Dihydrochloride

NCI Thesaurus Code: C999 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0051733  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
1H-benz(de)isoquinoline-1,3(2H)-dione, 5-amino-2-(2-(dimethylamino)ethyl)
Amonafide
amonafide
AMONAFIDE DIHYDROCHLORIDE
Amonafide Dihydrochloride
Amonafide Hydrochloride
Benzisoquinolinedione
BIDA
M-FA-142
Nafidimide
Quinamed

External Source Codes: 
CAS Registry Number 150091-68-2 (see NLM ChemIDplus info)
FDA UNII Code 2UAV344O66
NSC Code 308847 (see NCI DTP info)
PDQ Closed Trial Search ID 40214
PDQ Open Trial Search ID 40214 (check for NCI PDQ open clinical trial info)
UMLS CUI C0051733

Other Properties:
Name Value (qualifiers indented underneath)
Chemical_Formula C16H17N3O2.2ClH
code C999
Contributing_Source FDA
Legacy_Concept_Name Amonafide
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C999

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