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Version: 17.06d (Release date: 2017-06-26)
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Metyrosine (Code C998)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Metyrosine

Definition: A methylated tyrosine, a catecholamine synthesis antagonist with antihypertensive property. Metyrosine competitively inhibits tyrosine 3-monooxygenase, an enzyme that activates molecular oxygen to catalyze the hydroxylation of tyrosine to dihydroxyphenylalanine (Dopa), an intermediate to catecholamine (dopamine, norepinephrine, and epinephrine) production. This agent reduces the elevated levels of catecholamines associated with pheochromocytoma, thereby preventing hypertension.

Label: Metyrosine

NCI Thesaurus Code: C998 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0886584  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Alpha-methyl-p-tyrosine
Demser
L-588357-0
methyl-tyrosine
Metirosine
Metyrosine
METYROSINE
MK-781

External Source Codes: 
CAS Registry Number 672-87-7 (see NLM ChemIDplus info)
FDA UNII Code DOQ0J0TPF7
ChEBI ID CHEBI:6912 (see ChEBI info)
PDQ Closed Trial Search ID 39501
PDQ Open Trial Search ID 39501 (check for NCI PDQ open clinical trial info)
UMLS CUI C0886584

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C10H13NO3
code C998
Contributing_Source FDA
Legacy_Concept_Name Metyrosine
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C998

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