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Version: 16.11d (Release date: 2016-11-28)
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Erythrocyte-encapsulated L-asparaginase Suspension (Code C99767)

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Terms & Properties

Preferred Name: Erythrocyte-encapsulated L-asparaginase Suspension

Definition: A suspension of erythrocytes encapsulating L-asparaginase with potential antineoplastic activity. Upon administration of erythrocyte-encapsulated L-asparaginase suspension, L-asparagine is hydrolyzed to L-aspartic acid and ammonia in plasma, thereby depleting tumor cells of asparagine. Due to low asparagine synthetase activity in tumor cells, de novo synthesis of asparagine is suppressed within tumor cells. Shortage of asparagine prevents synthesis of important proteins necessary for tumor cell growth. Encapsulation of asparaginase in erythrocytes decreases the immunogenicity of exogenous protein, enhances its circulation time and may limit toxicity.

Display Name: Erythrocyte-encapsulated L-asparaginase Suspension

Label: Erythrocyte-encapsulated L-asparaginase Suspension

NCI Thesaurus Code: C99767 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL433492  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Erythrocyte-encapsulated L-asparaginase Suspension
GRASPA

External Source Codes: 
PDQ Closed Trial Search ID 724517
PDQ Open Trial Search ID 724517 (check for NCI PDQ open clinical trial info)
NCI META CUI CL433492

Other Properties:
Name Value (qualifiers indented underneath)
code C99767
Contributing_Source CTRP
Semantic_Type Enzyme
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C99767

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