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Version: 17.02d (Release date: 2016-02-27)
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Globo H-KLH Immunostimulant OPT-822 (Code C99766)

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Terms & Properties

Preferred Name: Globo H-KLH Immunostimulant OPT-822

Definition: A carbohydrate-based immunostimulant comprised of the Globo H hexasaccharide 1 (Globo H) epitope linked to the immunostimulant carrier protein keyhole limpet hemocyanin (KLH), with potential antineoplastic activity. Upon administration of Globo H-KLH immunostimulant OPT-822, the carbohydrate antigen Globo H may stimulate a cytotoxic T-lymphocyte (CTL) response against Globo H-expressing tumor cells, thereby decreasing tumor cell proliferation. Globo H is a tumor associated antigen (TAA) commonly found on a variety of tumor cells including breast cancer cells. KLH improves antigenic immune recognition and T-cell responses.

Display Name: Globo H-KLH Immunostimulant OPT-822

Label: Globo H-KLH Immunostimulant OPT-822

NCI Thesaurus Code: C99766 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL433491  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Globo H-KLH Immunostimulant OPT-822
OPT-822

External Source Codes: 
PDQ Closed Trial Search ID 724401
PDQ Open Trial Search ID 724401 (check for NCI PDQ open clinical trial info)
NCI META CUI CL433491

Other Properties:
Name Value (qualifiers indented underneath)
code C99766
Contributing_Source CTRP
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C99766

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