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Version: 17.06d (Release date: 2017-06-26)
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Oral Aminolevulinic Acid Hydrochloride (Code C99763)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Oral Aminolevulinic Acid Hydrochloride

Definition: A powder for an oral solution comprised of the hydrochloride salt of 5-aminolevulinic acid (ALA) with a potential application for photodynamic therapy. After oral administration, ALA is converted intracellularly into the photosensitizer protoporphyrin IX (PpIX). Upon exposure to light of appropriate wavelength (violet to blue range), excited PpIX emits a characteristic red fluorescence which could facilitate guided resection, and generates excited singlet oxygen molecules that could kill cells when appropriate laser dosage is applied. ALA is preferentially taken up by and accumulates in many types of cancer cells compared to normal, healthy cells. Consequently, cancer cells can be visualized and can be distinguished from normal, healthy cells.

Display Name: Oral Aminolevulinic Acid Hydrochloride

Label: Oral Aminolevulinic Acid Hydrochloride

NCI Thesaurus Code: C99763 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL433488  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
5-Aminolevulinic Acid Hydrochloride, Oral
Gliolan
Oral 5-ALA
Oral Aminolevulinic Acid Hydrochloride

External Source Codes: 
PDQ Closed Trial Search ID 723865
PDQ Open Trial Search ID 723865 (check for NCI PDQ open clinical trial info)
NCI META CUI CL433488

Other Properties:
     Name Value (qualifiers indented underneath)
code C99763
Contributing_Source CTRP
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C99763

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