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Version: 17.06d (Release date: 2017-06-26)
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Radotinib Hydrochloride (Code C99644)

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Terms & Properties

Preferred Name: Radotinib Hydrochloride

Definition: An orally available, hydrochloride salt form of radotinib, a second-generation tyrosine kinase inhibitor of Bcr-Abl fusion protein and the platelet-derived growth factor receptor (PDGFR), with potential antineoplastic activity. Upon administration, radotinib specifically inhibits the Bcr-Abl fusion protein, an abnormal enzyme expressed in Philadelphia chromosome positive chronic myeloid leukemia (CML) cells. In addition, this agent also inhibits PDGFR thereby blocking PDGFR-mediated signal transduction pathways. The inhibitory effect of radotinib on these specific tyrosine kinases may decrease cellular proliferation and inhibit angiogenesis. This agent has shown potent efficacy in CML cells that are resistant to the first-generation standard tyrosine kinase inhibitors, such as imatinib, nilotinib and dasatinib. PDGFR, upregulated in many tumor cell types, is a receptor tyrosine kinase essential to cell migration and the development of the microvasculature.

Label: Radotinib Hydrochloride

NCI Thesaurus Code: C99644 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL433306  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
4-Methyl-N-(3-(4-methylimidazol-1-yl)-5-trifluoromethylphenyl)-3-(4-(pyrazin-2-yl)pyrimidin-2-ylamino)benzamide Hydrochloride
IY5511HCl
Radotinib Hydrochloride

External Source Codes: 
PDQ Closed Trial Search ID 723999
PDQ Open Trial Search ID 723999 (check for NCI PDQ open clinical trial info)
NCI META CUI CL433306

Other Properties:
     Name Value (qualifiers indented underneath)
code C99644
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C99644

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