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Version: 17.06d (Release date: 2017-06-26)
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pbi-shRNA STMN1 Lipoplex (Code C99639)

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Terms & Properties

Preferred Name: pbi-shRNA STMN1 Lipoplex

Definition: A proprietary RNA interference construct consisting of bifunctional short hairpin RNAs (shRNA) against human stathmin 1 (STMN1) encapsulated in the cationic bilamellar invaginated vesicle lipoplex (LP) with potential antineoplastic activity. pbi-shRNA STMN1 LP contains 2 stem-loop structures encoded by a plasmid vector. Upon intratumoral administration, one shRNA unit with a perfectly matched sequence renders the suppression of STMN1 mRNA translation (mRNA sequestration and cleavage-independent degradation) while the other unit with an imperfectly matched sequence renders STMN1 mRNA degradation via RNase H-like cleavage (cleavage-dependent mRNA silencing). The suppression of STMN1 expression in tumor cells result in a reduction of tumor cell proliferation. STMN1, a ubiquitous cytosolic phosphoprotein and tubulin modulator that plays a key role in mitosis, is overexpressed in a variety of tumors and correlates with poor prognosis.

Label: pbi-shRNA STMN1 Lipoplex

NCI Thesaurus Code: C99639 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL433303  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
pbi-shRNA STMN1 Lipoplex
pbi-shRNA STMN1 LP

External Source Codes: 
PDQ Closed Trial Search ID 722324
PDQ Open Trial Search ID 722324 (check for NCI PDQ open clinical trial info)
NCI META CUI CL433303

Other Properties:
     Name Value (qualifiers indented underneath)
code C99639
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C99639

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