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Version: 17.06d (Release date: 2017-06-26)
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iodine I 131 NM404 (Code C99637)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: iodine I 131 NM404

Definition: A phospholipid ether analog labeled with iodine I 131, with potential radiotherapeutic and radioimaging potential upon positron emission tomography (PET). Upon administration, iodine I 131 NM404 selectively accumulates in and retains within tumor cells for a prolonged period of time due to the decreased activity of a phospholipase D (PLD), most likely isoform 1 of PLD, in tumor cells compared to normal cells. As tumor cells are unable to metabolize and eliminate MN404, tumor cells can be visualized upon PET imaging. In addition, iodine I 131 NM404 selectively delivers a cytotoxic dose of iodine I 131 to the tumor cells. PLD is an enzyme found in the cell membrane of normal cells that degrades phospholipids.

Label: iodine I 131 NM404

NCI Thesaurus Code: C99637 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL433302  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
131I-NM404
[(131)I]NM404
iodine I 131 NM404

External Source Codes: 
PDQ Closed Trial Search ID 722308
PDQ Open Trial Search ID 722308 (check for NCI PDQ open clinical trial info)
NCI META CUI CL433302

Other Properties:
     Name Value (qualifiers indented underneath)
code C99637
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Indicator, Reagent, or Diagnostic Aid

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C99637

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