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Version: 16.11d (Release date: 2016-11-28)
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Iodine I 124 Monoclonal Antibody 8H9 (Code C99632)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Iodine I 124 Monoclonal Antibody 8H9

Definition: A radioimmunoconjugate consisting of the iodine I 124-radiolabeled murine IgG1 monoclonal antibody (MoAb) 8H9 directed against the cell surface glycoprotein CD276 (4Ig-B7-H3) with potential for radioimaging using positron emission tomography (PET). Through convection enhanced delivery, iodine I 124 monoclonal antibody 8H9 binds to the 4Ig domain of CD276, in turn CD276 expressing tumor cells may be visualized upon PET imaging of the iodine I 124 moiety. CD276, a tumor associated antigen and member of the B7 family of co-stimulatory proteins, suppresses natural killer (NK) cell and cytotoxic T-lymhocyte activation; it is expressed on the cell membranes of a wide variety of tumors of neuroectodermal, mesenchymal and epithelial origin and its expression is associated with increased aggressiveness, poor prognosis and resistance.

Display Name: Iodine I 124 Monoclonal Antibody 8H9

Label: Iodine I 124 Monoclonal Antibody 8H9

NCI Thesaurus Code: C99632 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL433298  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
124I-8H9
Iodine I 124 MOAB 8H9
Iodine I 124 Monoclonal Antibody 8H9

External Source Codes: 
PDQ Closed Trial Search ID 722029
PDQ Open Trial Search ID 722029 (check for NCI PDQ open clinical trial info)
NCI META CUI CL433298

Other Properties:
Name Value (qualifiers indented underneath)
code C99632
Contributing_Source CTRP
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Indicator, Reagent, or Diagnostic Aid

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C99632

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