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Version: 17.06d (Release date: 2017-06-26)
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SR-T100 Gel (Code C99460)

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Terms & Properties

Preferred Name: SR-T100 Gel

Definition: A cutaneous gel preparation containing an extract from Solanum incanum with potential antineoplastic activity. SR-T100 gel contains high amounts of the steroidal alkaloid glycoside solamargine. Solamargine is able to upregulate expression of tumor necrosis factor receptors 1 (TNFR1) and 6 (TNFRSF6 or Fas), and their signaling adaptors TNFR1-associated death domain, and Fas-associated death domain. In addition, this agent is able to upregulate expression of apoptosis promoter Bax, and suppress the expression of the anti-apoptotic proteins Bcl-xL and Bcl-2. Altogether, this induces apoptosis in tumor cells and may lead to an inhibition of tumor cell proliferation.

Label: SR-T100 Gel

NCI Thesaurus Code: C99460 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL433216  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
SR-T100
SR-T100 Gel

External Source Codes: 
PDQ Closed Trial Search ID 721725
PDQ Open Trial Search ID 721725 (check for NCI PDQ open clinical trial info)
NCI META CUI CL433216

Other Properties:
     Name Value (qualifiers indented underneath)
code C99460
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C99460

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