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Version: 17.06d (Release date: 2017-06-26)
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Recombinant Oncolytic Poliovirus PVS-RIPO (Code C99459)

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Terms & Properties

Preferred Name: Recombinant Oncolytic Poliovirus PVS-RIPO

Definition: A recombinant, live attenuated, nonpathogenic oncolytic virus containing the oral poliovirus Sabin type 1 in which the internal ribosomal entry site (IRES) is replaced with the IRES from human rhinovirus type 2 (HRV2), with potential antineoplastic activity. Upon intratumoral administration of recombinant oncolytic poliovirus PVS-RIPO, the poliovirus is selectively taken up by and replicates in tumor cells expressing CD155 (poliovirus receptor, PVR or NECL5) eventually causing tumor cell lysis. CD155, an oncofetal cell adhesion molecule and tumor antigen, is ectopically expressed in certain cancers, such as glioblastoma multiforme (GMB), and plays an important role in tumor cell migration, invasion, and metastasis. Due to the heterologous HRV2 IRES in this recombinant virus, PVS-RIPO only propagates in susceptible, nonneuronal cells (e.g., GBM).

Display Name: Recombinant Oncolytic Poliovirus PVS-RIPO

Label: Recombinant Oncolytic Poliovirus PVS-RIPO

NCI Thesaurus Code: C99459 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL433215  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Recombinant Oncolytic Poliovirus PVS-RIPO

External Source Codes: 
PDQ Closed Trial Search ID 721361
PDQ Open Trial Search ID 721361 (check for NCI PDQ open clinical trial info)

Other Properties:
     Name Value (qualifiers indented underneath)
code C99459
Contributing_Source CTRP
Semantic_Type Pharmacologic Substance
Semantic_Type Virus

Additional Concept Data: 
Defined Fully by Roles: No  


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