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Version: 17.06d (Release date: 2017-06-26)
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Alanosine (Code C994)

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Terms & Properties

Preferred Name: Alanosine

Definition: An amino acid analogue and antibiotic derived from the bacterium Streptomyces alanosinicus with antimetabolite and potential antineoplastic activities. L-alanosine inhibits adenylosuccinate synthetase, which converts inosine monophospate (IMP) into adenylosuccinate, an intermediate in purine metabolism. L-alanosine-induced disruption of de novo purine biosynthesis is potentiated by methylthioadenosine phosphorylase (MTAP) deficiency. The clinical use of this agent may be limited by its toxicity profile. MTAP is a key enzyme in the adenine and methionine salvage pathways.

NCI-GLOSS Definition: A substance that is being studied in the treatment of cancer. It belongs to the family of drugs called antimetabolites.

Label: Alanosine

NCI Thesaurus Code: C994 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0051066  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
L-2-Amino-3-(hydroxynitrosoamino)propionic Acid
L-2-Amino-3-[(N-nitroso)hydroxylamino]propionic Acid
L-2-Amino-3-[(N-nitroso)hydroxylamino]propionic acid
L-Alanosine Sodium

External Source Codes: 
CAS Registry Number 5854-93-3 (see NLM ChemIDplus info)
FDA UNII Code 2CNI71214Y
NSC Code 529469 (see NCI DTP info)
PDQ Closed Trial Search ID 39138
PDQ Open Trial Search ID 39138 (check for NCI PDQ open clinical trial info)
UMLS CUI C0051066

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C3H7N3O4
code C994
Contributing_Source FDA
Legacy_Concept_Name L-Alanosine
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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