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Version: 17.06d (Release date: 2017-06-26)
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Dexanabinol (Code C99381)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Dexanabinol

Definition: A synthetic, terpene-based cannabinoid derivative devoid of cannabinoid receptors 1 and 2 agonist activity and with potential neuroprotective, antiinflammatory and antineoplastic activities. Functioning as an N-Methyl-D-aspartate (NMDA) receptor antagonist, dexanabinol protects neuronal cells against NMDA and glutamate neurotoxicity. This agent also scavenges peroxy radicals and protects neurons from the damages of reactive oxygen species. Furthermore, dexanabinol inhibits the activity of nuclear factor kappa B (NF-kB), thereby preventing the expression of NF-kB target genes, such as tumor necrosis factor alpha, cytokines and inducible nitric oxide synthase. As a result, this agent may restore apoptotic processes in cancerous cells. NF-kB is activated in a variety of cancer cells and plays a key role in the regulation of apoptosis and cellular proliferation.

Display Name: Dexanabinol

Label: Dexanabinol

NCI Thesaurus Code: C99381 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0526471  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
1,1-Dimethylheptyl-11-hydroxytetrahydrocannabinol
7-Hydroxy-delta-6-tetrahydrocannabinoldimethylheptyl
Dexanabinol
DEXANABINOL
HU-211

External Source Codes: 
CAS Registry Number 112924-45-5 (see NLM ChemIDplus info)
FDA UNII Code R6VT8U5372
PDQ Closed Trial Search ID 720043
PDQ Open Trial Search ID 720043 (check for NCI PDQ open clinical trial info)
UMLS CUI C0526471

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C25H38O3
code C99381
Contributing_Source CTRP
Contributing_Source FDA
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C99381

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