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Version: 16.10e (Release date: 2016-10-31)
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pan-PIM Kinase Inhibitor AZD1208 (Code C99380)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: pan-PIM Kinase Inhibitor AZD1208

Definition: An orally available, small molecule inhibitor of PIM kinases with potential antineoplastic activity. Pan-PIM kinase inhibitor AZD1208 inhibits the activities of PIM1, PIM2 and PIM3 serine/threonine kinases, which may result in the interruption of the G1/S phase cell cycle transition, thereby causing cell cycle arrest and inducing apoptosis in cells that overexpress PIMs. The growth inhibition of several leukemia cell lines by this agent is correlated with the expression levels of PIM1, which is the substrate of STAT transcription factors. PIM kinases are downstream effectors of many cytokine and growth factor signaling pathways and are upregulated in various malignancies.

Display Name: pan-PIM Kinase Inhibitor AZD1208

Label: pan-PIM Kinase Inhibitor AZD1208

NCI Thesaurus Code: C99380 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C3274705  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
AZD1208
pan-PIM Kinase Inhibitor AZD1208

External Source Codes: 
PDQ Closed Trial Search ID 720042
PDQ Open Trial Search ID 720042 (check for NCI PDQ open clinical trial info)
UMLS CUI C3274705

Other Properties:
Name Value (qualifiers indented underneath)
code C99380
Contributing_Source CTRP
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C99380

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