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Version: 16.11d (Release date: 2016-11-28)
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SDF-1-targeted agent NOX-A12 (Code C99379)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: SDF-1-targeted agent NOX-A12

Definition: A 45-mer L-stereoisomer RNA oligonucleotide linked to a 40 kDa polyethyleneglycol that targets the small chemokine stromal cell-derived factor 1 (SDF-1 or CXCL12) with potential antineoplastic and hematopoietic stem cell-mobilization activities. SDF-1 targeted agent NOX-A12 specifically binds to SDF-1 thereby preventing the binding of SDF-1 to its receptors CXCR4 and CXCR7 blocking the subsequent receptor activation. This may prevent angiogenesis, tumor cell proliferation, invasion and metastasis and could sensitize tumor cells to chemotherapy. In addition, inhibition of SDF-1/CXCR4 interaction may induce mobilization of hematopoietic cells from the bone marrow into blood. The unique mirror-image configuration of this agent renders it resistant to hydrolysis and does not hybridize with native nucleic acids. Furthermore, this agent does not induce the innate immune response and has shown a favorable immunogenicity profile.

Label: SDF-1-targeted agent NOX-A12

NCI Thesaurus Code: C99379 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C3274704  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
NOX-A12
SDF-1-targeted agent NOX-A12

External Source Codes: 
PDQ Closed Trial Search ID 719932
PDQ Open Trial Search ID 719932 (check for NCI PDQ open clinical trial info)
UMLS CUI C3274704

Other Properties:
Name Value (qualifiers indented underneath)
code C99379
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C99379

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