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Version: 16.11d (Release date: 2016-11-28)
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Nelipepimut-S Plus GM-CSF Vaccine (Code C99228)

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Terms & Properties

Preferred Name: Nelipepimut-S Plus GM-CSF Vaccine

Definition: A cancer peptide vaccine comprised of a human leukocyte antigen (HLA) A2/A3 restricted HER2/neu (ERBB2) peptide from the extracellular domain of the HER2 protein (E75 peptide) and combined with the immunoadjuvant granulocyte-macrophage colony-stimulating factor (GM-CSF), with potential immunomodulating and antineoplastic activity. Upon intradermal injection, nelipepimut-S plus GM-CSF vaccine may induce a specific cytotoxic T-lymphocyte (CTL) response against HER2/neu-expressing tumor cell types. HER2/neu, a tumor-associated antigen and a member of the epidermal growth factor receptor family of tyrosine kinases, is overexpressed in various tumor cell types. GM-CSF potentiates the antitumor immune response.

Display Name: Nelipepimut-S Plus GM-CSF Vaccine

Label: Nelipepimut-S Plus GM-CSF Vaccine

NCI Thesaurus Code: C99228 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL433057  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
E75 Plus GM-CSF
E75 Vaccine Plus GM-CSF
HLA A2/A3-Restricted HER-2/neu Peptide Vaccine Plus GM-CSF
Nelipepimut-S Plus GM-CSF Vaccine
Nelipepimut-S Plus Sargramostim
NeuVax Plus GM-CSF

External Source Codes: 
PDQ Closed Trial Search ID 719080
PDQ Open Trial Search ID 719080 (check for NCI PDQ open clinical trial info)
NCI META CUI CL433057

Other Properties:
Name Value (qualifiers indented underneath)
code C99228
Contributing_Source CTRP
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C99228

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