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Version: 17.06d (Release date: 2017-06-26)
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PI3K delta/gamma Inhibitor IPI-145 (Code C99225)

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Terms & Properties

Preferred Name: PI3K delta/gamma Inhibitor IPI-145

Definition: An orally bioavailable, highly selective and potent small molecule inhibitor of the delta and gamma isoforms of phosphoinositide-3 kinase (PI3K) with potential immunomodulating and antineoplastic activities. Upon administration, PI3K delta/gamma inhibitor IPI 145 prevents the activation of the PI3K delta/gamma-mediated signaling pathways which may lead to a reduction in cellular proliferation in PI3K delta/gamma-expressing tumor cells. Unlike other isoforms of PI3K, the delta and gamma isoforms are overexpressed primarily in hematologic malignancies and inflammatory and autoimmune diseases. By selectively targeting these PI3K isoforms, PI3K signaling in normal, non-neoplastic cells is minimally or not affected which would result in a more favorable side effect profile.

Display Name: PI3K delta/gamma Inhibitor IPI-145

Label: PI3K delta/gamma Inhibitor IPI-145

NCI Thesaurus Code: C99225 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C3274621  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
IPI-145
PI3K delta/gamma Inhibitor IPI-145

External Source Codes: 
PDQ Closed Trial Search ID 718963
PDQ Open Trial Search ID 718963 (check for NCI PDQ open clinical trial info)
UMLS CUI C3274621

Other Properties:
     Name Value (qualifiers indented underneath)
code C99225
Contributing_Source CTRP
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C99225

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