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Version: 17.06d (Release date: 2017-06-26)
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Bi-functional Alkylating Agent VAL-083 (Code C99224)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Bi-functional Alkylating Agent VAL-083

Definition: A bi-functional alkylating agent, with potential antineoplastic activity. Upon administration, VAL-083 crosses the blood brain barrier (BBB) and appears to be selective for tumor cells. This agent alkylates and crosslinks DNA which ultimately leads to a reduction in cancer cell proliferation. In addition, VAL-083 does not show cross-resistance to other conventional chemotherapeutic agents and has a long half-life in the brain.

Display Name: Bi-functional Alkylating Agent VAL-083

Label: Bi-functional Alkylating Agent VAL-083

NCI Thesaurus Code: C99224 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL433054  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Bi-functional Alkylating Agent VAL-083
VAL-083
VAL083

External Source Codes: 
PDQ Closed Trial Search ID 718929
PDQ Open Trial Search ID 718929 (check for NCI PDQ open clinical trial info)
NCI META CUI CL433054

Other Properties:
     Name Value (qualifiers indented underneath)
code C99224
Contributing_Source CTRP
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C99224

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