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Version: 17.06d (Release date: 2017-06-26)
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Allogeneic CD19-specific CAR-modified CD8 Plus Central Memory-derived Virus-specific T Cells (Code C99215)

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Terms & Properties

Preferred Name: Allogeneic CD19-specific CAR-modified CD8 Plus Central Memory-derived Virus-specific T Cells

Definition: A preparation of allogeneic Epstein-Barr virus (EBV)- and human cytomegalovirus (CMV)-specific CD8+ central memory-derived T effector-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) anti-CD19/CD3 zeta chain fusion protein coupled to the intracellular signal domain of CD28 antigen, with potential immunostimulating, anti-viral and antineoplastic activities. Upon infusion, allogeneic CD19-specific CAR-modified CD8+ central memory-derived virus-specific T cells directs the T-lymphocytes to CD19-expressing tumor cells, stimulating a selective toxicity to tumor cells which may eventually result in tumor cell lysis. CD19 antigen is a B-cell specific cell surface antigen expressed in all B-cell lineage malignancies. The viral specific T-cells exert antiviral immunity.

Label: Allogeneic CD19-specific CAR-modified CD8 Plus Central Memory-derived Virus-specific T Cells

NCI Thesaurus Code: C99215 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL433046  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Allogeneic CD19-specific CAR-modified CD8 Plus Central Memory-derived Virus-specific T Cells
Allogeneic CD19CAR-TCM Cells

External Source Codes: 
PDQ Closed Trial Search ID 717909
PDQ Open Trial Search ID 717909 (check for NCI PDQ open clinical trial info)
NCI META CUI CL433046

Other Properties:
     Name Value (qualifiers indented underneath)
code C99215
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C99215

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