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Version: 17.06d (Release date: 2017-06-26)
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Monobenzone (Code C992)

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Terms & Properties

Preferred Name: Monobenzone

Definition: A monobenzyl ether of hydroquinone with topical depigmentation activity. Although the exact mechanism of action of depigmentation is unknown, the metabolites of monobenzone appear to have a cytotoxic effect on melanocytes. Furthermore, the depigmentation effect might be mediated through the inhibition of tyrosinase, which is essential in the synthesis of melanin pigments, thereby causing permanent depigmentation of the skin.

Label: Monobenzone

NCI Thesaurus Code: C992 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0050962  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Hydroquinone monobenzyl ether
Monobenzyl ether hydroquinone
monobenzyl ether of hydroquinone

External Source Codes: 
CAS Registry Number 103-16-2 (see NLM ChemIDplus info)
ChEBI ID CHEBI:34380 (see ChEBI info)
NSC Code 33918 (see NCI DTP info)
PDQ Closed Trial Search ID 39494
PDQ Open Trial Search ID 39494 (check for NCI PDQ open clinical trial info)
UMLS CUI C0050962

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Vitiligo
Chemical_Formula C13H12O2
code C992
Contributing_Source FDA
Legacy_Concept_Name Monobenzone
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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