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Version: 17.12d (Release date: 2017-12-26)
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AKT Inhibitor ARQ 092 (Code C99172)

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Terms & Properties

Preferred Name: AKT Inhibitor ARQ 092

Definition: An orally bioavailable inhibitor of the serine/threonine protein kinase AKT (protein kinase B) with potential antineoplastic activity. AKT inhibitor ARQ 092 binds to and inhibits the activity of AKT in a non-ATP competitive manner, which may result in the inhibition of the PI3K/AKT signaling pathway. This may lead to the reduction in tumor cell proliferation and the induction of tumor cell apoptosis. The AKT signaling pathway is often deregulated in cancer and is associated with tumor cell proliferation, survival and migration.

Label: AKT Inhibitor ARQ 092

NCI Thesaurus Code: C99172 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C3274586  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
AKT Inhibitor ARQ 092
ARQ 092

External Source Codes: 
PDQ Closed Trial Search ID 717768
PDQ Open Trial Search ID 717768 (check for NCI PDQ open clinical trial info)
UMLS CUI C3274586

Other Properties:
     Name Value (qualifiers indented underneath)
code C99172
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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