skip navigation links
National Cancer Institute
EVS Logo NCI Term Browser Enterprise Vocabulary Services
Terminologies Value Sets Mappings
Version: 17.06d (Release date: 2017-06-26)
SearchBox Top
SearchBox Bottom
Indium In 111 Anti-EGFR Monoclonal Antibody ABT-806 (Code C99169)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Indium In 111 Anti-EGFR Monoclonal Antibody ABT-806

Definition: A radioimmunoconjugate composed of a humanized monoclonal antibody IgG1 directed against the epidermal growth factor receptor (EGFR) and labeled with the radioisotope indium In 111, with potential radioimaging activity. Indium In 111 anti-EGFR monoclonal antibody ABT-806 binds to a specific epitope of either wild-type or EGFR variant III mutant on tumor cells, thereby allowing imaging of EGFR-expressing tumor cells using gamma scintigraphy. ABT-806 is the humanized version derived from the predecessor chimeric monoclonal antibody 806. EGFR, a receptor tyrosine kinase overexpressed on the cell surfaces of many tumor cell types, plays a key role in tumor cell proliferation.

Label: Indium In 111 Anti-EGFR Monoclonal Antibody ABT-806

NCI Thesaurus Code: C99169 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL433018  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
111-Indium-ABT806
Indium In 111 ABT-806
Indium In 111 Anti-EGFR Monoclonal Antibody ABT-806

External Source Codes: 
PDQ Closed Trial Search ID 717760
PDQ Open Trial Search ID 717760 (check for NCI PDQ open clinical trial info)
NCI META CUI CL433018

Other Properties:
     Name Value (qualifiers indented underneath)
code C99169
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Indicator, Reagent, or Diagnostic Aid

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C99169

Mainbox Bottom