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Version: 17.06d (Release date: 2017-06-26)
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Indium In 111 Anti-EGFR Monoclonal Antibody ABT-806 (Code C99169)

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Terms & Properties

Preferred Name: Indium In 111 Anti-EGFR Monoclonal Antibody ABT-806

Definition: A radioimmunoconjugate composed of a humanized monoclonal antibody IgG1 directed against the epidermal growth factor receptor (EGFR) and labeled with the radioisotope indium In 111, with potential radioimaging activity. Indium In 111 anti-EGFR monoclonal antibody ABT-806 binds to a specific epitope of either wild-type or EGFR variant III mutant on tumor cells, thereby allowing imaging of EGFR-expressing tumor cells using gamma scintigraphy. ABT-806 is the humanized version derived from the predecessor chimeric monoclonal antibody 806. EGFR, a receptor tyrosine kinase overexpressed on the cell surfaces of many tumor cell types, plays a key role in tumor cell proliferation.

Label: Indium In 111 Anti-EGFR Monoclonal Antibody ABT-806

NCI Thesaurus Code: C99169 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL433018  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Indium In 111 ABT-806
Indium In 111 Anti-EGFR Monoclonal Antibody ABT-806

External Source Codes: 
PDQ Closed Trial Search ID 717760
PDQ Open Trial Search ID 717760 (check for NCI PDQ open clinical trial info)

Other Properties:
     Name Value (qualifiers indented underneath)
code C99169
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Indicator, Reagent, or Diagnostic Aid

Additional Concept Data: 
Defined Fully by Roles: No  


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