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Version: 16.11d (Release date: 2016-11-28)
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Yttrium Y 90-labeled Anti-FZD10 Monoclonal Antibody OTSA101 (Code C99168)

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Terms & Properties

Preferred Name: Yttrium Y 90-labeled Anti-FZD10 Monoclonal Antibody OTSA101

Definition: A radioimmunoconjugate composed of a humanized monoclonal antibody (MoAb) OTSA101 against FZD10 and labeled with yttrium y 90, with potential antineoplastic activity. The MoAb moiety of yttrium Y 90-labeled anti-FZD10 monoclonal antibody OTSA101 binds to FZD10, thereby delivering a cytotoxic dose of beta radiation to FZD10 positive tumor cells. FZD10 (also called CD350), a member of the Frizzled family of G protein-coupled receptors that is involved in the Wnt/beta-catenin/TCF signaling pathway, is overexpressed in a variety of cancer cell types but undetectable in normal, healthy human tissues except for the placenta.

Label: Yttrium Y 90-labeled Anti-FZD10 Monoclonal Antibody OTSA101

NCI Thesaurus Code: C99168 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL433017  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
OTSA101-DTPA-90Y
Yttrium Y 90-labeled Anti-FZD10 Monoclonal Antibody OTSA101

External Source Codes: 
PDQ Closed Trial Search ID 717536
PDQ Open Trial Search ID 717536 (check for NCI PDQ open clinical trial info)
NCI META CUI CL433017

Other Properties:
Name Value (qualifiers indented underneath)
code C99168
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C99168

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