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Version: 17.06d (Release date: 2017-06-26)
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Entolimod (Code C99166)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Entolimod

Definition: A polypeptide derived from the Salmonella filament protein flagellin with potential radioprotective and anticancer activities. As a toll-like receptor 5 (TLR5) agonist, entolimod binds to and activates TLR5 thereby stimulating tumor necrosis factor production and activating nuclear factor kappa B (NF-kB). This induces NF-kB-mediated signaling pathways and inhibits the induction of apoptosis. This may prevent apoptosis in normal, healthy cells during radiotherapy of cancerous cells and may allow for increased doses of ionizing radiation. In addition, entolimod may inhibit radiation-independent proliferation in TLR5-expressing tumor cells.

Display Name: Entolimod

Label: Entolimod

NCI Thesaurus Code: C99166 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2353146  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
CBLB502
Entolimod
TLR5 Agonist CBLB502

External Source Codes: 
PDQ Closed Trial Search ID 717513
PDQ Open Trial Search ID 717513 (check for NCI PDQ open clinical trial info)
UMLS CUI C2353146

Other Properties:
     Name Value (qualifiers indented underneath)
code C99166
Contributing_Source CTRP
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C99166

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