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Version: 17.06d (Release date: 2017-06-26)
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DNA-dependent Protein Kinase-targeting siDNA DT01 (Code C99165)

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Terms & Properties

Preferred Name: DNA-dependent Protein Kinase-targeting siDNA DT01

Definition: A proprietary preparation of small interfering DNA (siDNA) molecules with potential chemo/radiosensitizing activity. By mimicking DNA double strand breaks (DSBs), DNA-dependent protein kinase-targeting siDNA DT01 inhibits the non-homologous end joining (NHEJ) process, one of the main DNA repair mechanisms, via binding to and activating DNA-dependent protein kinase (DNA-PK), a core component of the NHEJ complex. DNA-PK activation causes hyper-phosphorylation of histone variant H2AX on DNA and results in a different phosphorylated pattern of H2AX upon ionizing radiation treatment. This ultimately interferes with the repair of DNA DSBs during chemo- or radiotherapy, thereby increasing tumor cell death. The enhanced ability of tumor cells to repair DSBs plays a major role in the resistance of tumor cells to chemo- and radiotherapy.

Label: DNA-dependent Protein Kinase-targeting siDNA DT01

NCI Thesaurus Code: C99165 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL433015  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
DNA-dependent Protein Kinase-targeting siDNA DT01
DNA-PK-targeting siDNA DT01
DT01

External Source Codes: 
PDQ Closed Trial Search ID 717510
PDQ Open Trial Search ID 717510 (check for NCI PDQ open clinical trial info)
NCI META CUI CL433015

Other Properties:
     Name Value (qualifiers indented underneath)
code C99165
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C99165

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