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Version: 17.06d (Release date: 2017-06-26)
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Tropomyosin Receptor Kinase Inhibitor AZD7451 (Code C99161)

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Terms & Properties

Preferred Name: Tropomyosin Receptor Kinase Inhibitor AZD7451

Definition: A tropomyosin receptor kinase (TRK) inhibitor with potential antineoplastic activity. AZD7451 binds to TRK, thereby preventing the neurotrophin-TRK interaction and subsequent TRK activation. This may eventually result in an inhibition of tumor cell proliferation in TRK-expressing tumor cells. TRK, a receptor tyrosine kinase activated by neurotrophins, is mutated in a variety of cancer cell types and plays an important role in tumor cell growth, invasion and survival.

Display Name: Tropomyosin Receptor Kinase Inhibitor AZD7451

Label: Tropomyosin Receptor Kinase Inhibitor AZD7451

NCI Thesaurus Code: C99161 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C3274575  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
AZD7451
TRK Inhibitor AZD7451
Tropomyosin Receptor Kinase Inhibitor AZD7451

External Source Codes: 
PDQ Closed Trial Search ID 717230
PDQ Open Trial Search ID 717230 (check for NCI PDQ open clinical trial info)
UMLS CUI C3274575

Other Properties:
     Name Value (qualifiers indented underneath)
code C99161
Contributing_Source CTRP
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C99161

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