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National Cancer Institute
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Version: 17.06d (Release date: 2017-06-26)
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Icotinib Hydrochloride (Code C99160)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Icotinib Hydrochloride

Definition: An orally available quinazoline-based inhibitor of epidermal growth factor receptor (EGFR), with potential antineoplastic activity. Icotinib selectively inhibits the wild-type and several mutated forms of EGFR tyrosine kinase. This may lead to an inhibition of EGFR-mediated signal transduction and may inhibit cancer cell proliferation. EGFR, a receptor tyrosine kinase, has been upregulated in a variety of cancer cell types.

Display Name: Icotinib Hydrochloride

Label: Icotinib Hydrochloride

NCI Thesaurus Code: C99160 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL433010  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Icotinib Hydrochloride

External Source Codes: 
CAS Registry Number 1204313-51-8 (see NLM ChemIDplus info)
PDQ Closed Trial Search ID 717145
PDQ Open Trial Search ID 717145 (check for NCI PDQ open clinical trial info)

Other Properties:
     Name Value (qualifiers indented underneath)
code C99160
Contributing_Source CTRP
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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