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Version: 17.06d (Release date: 2017-06-26)
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Fluorine F 18 RGD-K5 (Code C99133)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Fluorine F 18 RGD-K5

Definition: A radiotracer composed of a cyclic triazole-containing the Arg-Gly-Asp (RGD) peptide (RGD-K5) radiolabeled with fluorine F 18, with potential alphaVbeta3 integrin imaging activity upon positron emission topography (PET). Upon administration, the RGD moiety of fluorine F 18 RGD-K5 selectively binds to alphaVbeta3 integrin. During PET, alphaVbeta3-expressing tumor cells can be visualized and the degree of tumor angiogenesis can be determined. AlphaVbeta3 integrin, a cell adhesion and signaling receptor, is upregulated in tumor vessel endothelial cells and has been associated with neovascularization, differentiation, proliferation of tumor cells, and metastasis.

Display Name: Fluorine F 18 RGD-K5

Label: Fluorine F 18 RGD-K5

NCI Thesaurus Code: C99133 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL432951  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
F18 RGD-K5
Fluorine F 18 RGD-K5

External Source Codes: 
PDQ Closed Trial Search ID 716083
PDQ Open Trial Search ID 716083 (check for NCI PDQ open clinical trial info)
NCI META CUI CL432951

Other Properties:
     Name Value (qualifiers indented underneath)
code C99133
Contributing_Source CTRP
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C99133

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