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Version: 17.06d (Release date: 2017-06-26)
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Idasanutlin (Code C99131)

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Terms & Properties

Preferred Name: Idasanutlin

Definition: An orally available, small molecule, antagonist of MDM2 (mouse double minute 2; Mdm2 p53 binding protein homolog), with potential antineoplastic activity. Idasanutlin binds to MDM2 blocking the interaction between the MDM2 protein and the transcriptional activation domain of the tumor suppressor protein p53. By preventing the MDM2-p53 interaction, p53 is not enzymatically degraded and the transcriptional activity of p53 is restored. This may lead to p53-mediated induction of tumor cell apoptosis. MDM2, a zinc finger nuclear phosphoprotein and negative regulator of the p53 pathway, is often overexpressed in cancer cells and has been implicated in cancer cell proliferation and survival.

Display Name: Idasanutlin

Label: Idasanutlin

NCI Thesaurus Code: C99131 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C3851180  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Idasanutlin
IDASANUTLIN
RG-7388
RG7388
RO-5503781
RO5503781

External Source Codes: 
FDA UNII Code QSQ883V35U
PDQ Closed Trial Search ID 715916
PDQ Open Trial Search ID 715916 (check for NCI PDQ open clinical trial info)
UMLS CUI C3851180

Other Properties:
     Name Value (qualifiers indented underneath)
code C99131
Contributing_Source CTRP
Contributing_Source FDA
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C99131

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