skip navigation links
National Cancer Institute
EVS Logo NCI Term Browser Enterprise Vocabulary Services
Terminologies Value Sets Mappings
Version: 17.04d (Release date: 2017-04-24)
SearchBox Top
SearchBox Bottom
AIM2(-1)/HT001(-1)/TAF1B(-1) Frameshift Peptide Vaccine (Code C99129)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: AIM2(-1)/HT001(-1)/TAF1B(-1) Frameshift Peptide Vaccine

Definition: A cancer vaccine containing the three frame shift peptides (FSP) AIM2(-1), HT001(-1) and TAF1B(-1), with potential immunomodulating activity. Upon administration, the AIM2(-1)/HT001(-1)/TAF1B(-1) FSP vaccine may induce an immune response against microsatellite instability (MSI) colorectal cancer-associated antigens. Frame shift mutations of AIM2 (absent in melanoma 2, an interferon-inducible protein), HT001 (asteroid homolog 1 or ASTE1, with an unknown function) and TAF1B (TATA box-binding protein-associated RNA polymerase I B, a transcription factor) are seen in MSI-positive colorectal cancers and may be associated with malignant transformation, tumor progression and the presence of tumor-infiltrating lymphocytes. These FSPs all have one-base deletions.

Label: AIM2(-1)/HT001(-1)/TAF1B(-1) Frameshift Peptide Vaccine

NCI Thesaurus Code: C99129 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL432947  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
AIM2(-1)/HT001(-1)/TAF1B(-1) Frameshift Peptide Vaccine
AIM2(-1)/HT001(-1)/TAF1B(-1) FSP Vaccine

External Source Codes: 
PDQ Closed Trial Search ID 715785
PDQ Open Trial Search ID 715785 (check for NCI PDQ open clinical trial info)
NCI META CUI CL432947

Other Properties:
     Name Value (qualifiers indented underneath)
code C99129
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C99129

Mainbox Bottom