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Version: 17.06d (Release date: 2017-06-26)
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hTERT mRNA/Survivin Peptide-double-loaded Autologous Dendritic Cell Vaccine (Code C99116)

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Terms & Properties

Preferred Name: hTERT mRNA/Survivin Peptide-double-loaded Autologous Dendritic Cell Vaccine

Definition: A cancer vaccine containing autologous dendritic cells (DCs) that are pulsed with mRNA encoding human telomerase reverse transcriptase (hTERT) and survivin peptide, with potential immunostimulatory and antineoplastic activities. Upon administration, hTERT mRNA/survivin peptide-double-loaded autologous dendritic cell vaccine may elicit an immune response against cancer cells expressing hTERT and survivin by activating cytotoxic T-cells (CTLs), natural killer cells (NKs), and B-lymphocytes. The tumor associated antigens (TAAs) hTERT, the catalytic subunit of human telomerase, and survivin, a member of the inhibitor of apoptosis (IAP) family of proteins, may be upregulated in certain tumor cell types and play key roles in tumor cell growth and survival.

Label: hTERT mRNA/Survivin Peptide-double-loaded Autologous Dendritic Cell Vaccine

NCI Thesaurus Code: C99116 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL432938  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
hTERT mRNA/Survivin Peptide-double-loaded Autologous Dendritic Cell Vaccine
Procure

External Source Codes: 
PDQ Closed Trial Search ID 715580
PDQ Open Trial Search ID 715580 (check for NCI PDQ open clinical trial info)
NCI META CUI CL432938

Other Properties:
     Name Value (qualifiers indented underneath)
code C99116
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C99116

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