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Version: 17.08d (Release date: 2017-08-28)
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PI3K alpha Inhibitor MLN1117 (Code C98844)

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Terms & Properties

Preferred Name: PI3K alpha Inhibitor MLN1117

Definition: An orally bioavailable inhibitor of the class I phosphoinositide 3-kinase (PI3K) alpha isoform with potential antineoplastic activity. PI3K alpha inhibitor MLN1117 selectively inhibits PI3K alpha kinase, including mutations of PIK3CA, in the PI3K/Akt/mTOR pathway, which may result in tumor cell apoptosis and growth inhibition in PI3K alpha-expressing tumor cells. By specifically targeting class I PI3K alpha, this agent may be more efficacious and less toxic than pan PI3K inhibitors. Dysregulation of the PI3K/Akt/mTOR pathway is frequently found in solid tumors and results in promoting tumor cell growth, survival, and resistance to chemotherapy and radiotherapy; PIK3CA, one of the most highly mutated oncogenes, encodes the p110-alpha catalytic subunit of the class I PI3K.

Display Name: PI3K alpha Inhibitor MLN1117

Label: PI3K alpha Inhibitor MLN1117

NCI Thesaurus Code: C98844 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL432860  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
INK1117
MLN-1117
MLN1117
PI3K alpha Inhibitor MLN1117
TAK-117
TAK 117

External Source Codes: 
PDQ Closed Trial Search ID 714372
PDQ Open Trial Search ID 714372 (check for NCI PDQ open clinical trial info)
NCI META CUI CL432860

Other Properties:
     Name Value (qualifiers indented underneath)
code C98844
Contributing_Source CTRP
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C98844

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