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National Cancer Institute
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Version: 17.06d (Release date: 2017-06-26)
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Poziotinib (Code C98838)

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Terms & Properties

Preferred Name: Poziotinib

Definition: An orally bioavailable, quinazoline-based, mall-molecular and irreversible pan-epidermal growth factor receptor (EGFR or HER) inhibitor with potential antineoplastic activity. Poziotinib inhibits EGFR (HER1 or ErbB1), HER2, HER4 and EGFR mutants, thereby inhibiting the proliferation of tumor cells that overexpress these receptors. EGFRs, cell surface receptor tyrosine kinases, are often upregulated in a variety of cancer cell types and play key roles in cellular proliferation and survival.

Display Name: Poziotinib

Label: Poziotinib

NCI Thesaurus Code: C98838 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C3180480  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)

External Source Codes: 
PDQ Closed Trial Search ID 715507
PDQ Open Trial Search ID 715507 (check for NCI PDQ open clinical trial info)
UMLS CUI C3180480

Other Properties:
     Name Value (qualifiers indented underneath)
code C98838
Contributing_Source CTRP
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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