skip navigation links
National Cancer Institute
EVS Logo NCI Term Browser Enterprise Vocabulary Services
Terminologies Value Sets Mappings
Version: 17.06d (Release date: 2017-06-26)
SearchBox Top
SearchBox Bottom
MEK 1/2 Inhibitor AS703988/MSC2015103B (Code C98832)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: MEK 1/2 Inhibitor AS703988/MSC2015103B

Definition: An orally bioavailable small-molecule inhibitor of mitogen-activated protein kinase kinase (MAP2K, MAPK/ERK kinase, or MEK) 1 and 2 with potential antineoplastic activity. MEK1/2 inhibitor AS703988/MSC2015103B selectively binds to and inhibits the activity of MEK1/2, preventing the activation of MEK1/2-dependent effector proteins and transcription factors, which may result in the inhibition of growth factor-mediated cell signaling and tumor cell proliferation. MEK1/2 are dual-specificity threonine/tyrosine kinases that play key roles in the activation of the RAS/RAF/MEK/ERK pathway that regulates cell growth and are often upregulated in a variety of tumor cell types.

Display Name: MEK 1/2 Inhibitor AS703988/MSC2015103B

Label: MEK 1/2 Inhibitor AS703988/MSC2015103B

NCI Thesaurus Code: C98832 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL432851  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
AS703988
AS703988/MSC2015103B
MEK 1/2 Inhibitor AS703988/MSC2015103B
MSC2015103B

External Source Codes: 
PDQ Closed Trial Search ID 714900
PDQ Open Trial Search ID 714900 (check for NCI PDQ open clinical trial info)
NCI META CUI CL432851

Other Properties:
     Name Value (qualifiers indented underneath)
code C98832
Contributing_Source CTRP
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C98832

Mainbox Bottom