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Version: 17.06d (Release date: 2017-06-26)
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Acivicin (Code C986)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Acivicin

Definition: A modified amino acid and structural analog of glutamine. Acivicin inhibits glutamine amidotransferases in the purine and pyrimidine biosynthetic pathways, thereby inhibiting tumor growth in cell lines dependent on glutamine metabolism. (NCI04)

Label: Acivicin

NCI Thesaurus Code: C986 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0050560  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
(S-(R*,R*))-4,5-Dihydro-alpha-amino-3-chloro-5-isoxazoleacetic Acid
Acivicin
ACIVICIN
AT-125
U-42126

External Source Codes: 
CAS Registry Number 42228-92-2 (see NLM ChemIDplus info)
FDA UNII Code O0X60K76I6
NSC Code 163501 (see NCI DTP info)
PDQ Closed Trial Search ID 39132
PDQ Open Trial Search ID 39132 (check for NCI PDQ open clinical trial info)
UMLS CUI C0050560

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C5H7ClN2O3
code C986
Contributing_Source FDA
Legacy_Concept_Name Acivicin
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C986

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