skip navigation links
National Cancer Institute
EVS Logo NCI Term Browser Enterprise Vocabulary Services
Terminologies Value Sets Mappings
Version: 17.06d (Release date: 2017-06-26)
SearchBox Top
SearchBox Bottom
Acitretin (Code C985)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Acitretin

Definition: An orally-active metabolite of the synthetic aromatic retinoic acid agent etretinate with potential antineoplastic, chemopreventive, anti-psoratic, and embryotoxic properties. Acitretin activates nuclear retinoic acid receptors (RAR), resulting in induction of cell differentiation, inhibition of cell proliferation, and inhibition of tissue infiltration by inflammatory cells. This agent may also inhibit tumor angiogenesis. (NCI04)

NCI-GLOSS Definition: A substance that is used in the prevention of cancer and in the treatment of psoriasis. It belongs to the family of drugs called retinoids.

Label: Acitretin

NCI Thesaurus Code: C985 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0050559  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
(All-E)-9-(4-Methoxy-2,3,6-trimethylphenyl)-3,7-dimethyl-2,4,6,8-nonatetraenoic Acid
acitretin
Acitretin
ACITRETIN
Etretin
Neotigason
Ro-10-1670
Ro 10-1670
Soriatane
Trimethylmethoxyphenyl-retinoic acid

External Source Codes: 
CAS Registry Number 55079-83-9 (see NLM ChemIDplus info)
FDA UNII Code LCH760E9T7
ChEBI ID CHEBI:50173 (see ChEBI info)
PDQ Closed Trial Search ID 43244
PDQ Open Trial Search ID 43244 (check for NCI PDQ open clinical trial info)
UMLS CUI C0050559

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Psoriasis; cutaneous T-cell lymphoma
Chemical_Formula C21H26O3
code C985
Contributing_Source FDA
Legacy_Concept_Name Acitretin
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C985

Mainbox Bottom