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Version: 16.10e (Release date: 2016-10-31)
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Ebselen-containing Oral Capsule SPI-1005 (Code C98398)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Ebselen-containing Oral Capsule SPI-1005

Definition: An oral capsule containing a proprietary formulation of the organoselenium compound ebselen, with potential anti-oxidant, anti-inflammatory and cytoprotective activity. Upon oral administration of SPI-1005, this agent mimics the activity of glutathione peroxidase (GPx) and can utilize glutathione to reduce other unstable molecules, thus preventing the formation of reactive oxygen species (ROS) and reducing oxidative stress on the cell. In the cochlea, this agent may prevent drug-induced injury to the auditory hair cells thereby preventing hearing loss. GPx is the main antioxidant enzyme in the cochlea and protects the inner ear from loud sounds and biochemical damage. In addition, ebselen is able to inhibit the activity of many enzymes involved in inflammation.

Label: Ebselen-containing Oral Capsule SPI-1005

NCI Thesaurus Code: C98398 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL432490  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Ebselen-containing Oral Capsule SPI-1005
SPI-1005

External Source Codes: 
PDQ Closed Trial Search ID 714508
PDQ Open Trial Search ID 714508 (check for NCI PDQ open clinical trial info)
NCI META CUI CL432490

Other Properties:
Name Value (qualifiers indented underneath)
code C98398
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C98398

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