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Version: 17.08d (Release date: 2017-08-28)
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Acarbose (Code C983)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Acarbose

Definition: A pseudotetrasaccharide and inhibitor of alpha-glucosidase and pancreatic alpha-amylase with antihyperglycemic activity. Acarbose binds to and inhibits alpha-glucosidase, an enteric enzyme found in the brush border of the small intestines that hydrolyzes oligosaccharides and disaccharides into glucose and other monosaccharides. This prevents the breakdown of larger carbohydrates into glucose and decreases the rise in postprandial blood glucose levels. In addition, acarbose inhibits pancreatic alpha-amylase which hydrolyzes complex starches to oligosaccharides in the small intestines.

Label: Acarbose

NCI Thesaurus Code: C983 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0050393  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
ACARBOSE
Acarbose
Bay g 5421
Glucobay
O-4,6-Dideoxy-4-[[(1S,4R,5S,6S)-4,5,6-trihydroxy-3-(hydroxymethyl)-2-cyclohexen-1-yl]amino]-alpha-D-glucopyranosyl-(1-4)-O-alpha-D-glucopyranosyl-(1-4)-D-glucose
Precose

External Source Codes: 
CAS Registry Number 56180-94-0 (see NLM ChemIDplus info)
FDA UNII Code T58MSI464G
ChEBI ID CHEBI:2376 (see ChEBI info)
PDQ Closed Trial Search ID 42140
PDQ Open Trial Search ID 42140 (check for NCI PDQ open clinical trial info)
UMLS CUI C0050393

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C25H43NO18
code C983
Contributing_Source FDA
Legacy_Concept_Name Acarbose
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C983

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