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Version: 17.06d (Release date: 2017-06-26)
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Recombinant MIP1-alpha Variant ECI301 (Code C98294)

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Terms & Properties

Preferred Name: Recombinant MIP1-alpha Variant ECI301

Definition: A recombinant form of a human macrophage inflammatory protein-1 alpha (MIP1-alpha) with a substitution of aspartate to alanine at position 26, with potential immunomodulating and radiotherapy potentiating activity. Intravenous administration of recombinant MIP1-alpha variant ECI301 after local tumor irradiation enhances the anti-tumor effect of ionizing radiation at the irradiated site as well as the antitumor effect at non-irradiated tumor sites (known as the abscopal effect). The abscopal effect appears to be attributed to this agent's ability to recruit and activate leukocytes, such as monocytes, dendritic cells, natural killer cells and T lymphocytes, thereby initiating an anti-tumor immune response against cancer cells. MIP1-alpha, also known as chemokine (C-C motif) ligand 3, is a ligand for the chemokine receptors CCR1, CCR4 and CCR5 that are involved in immune and inflammatory responses.

Display Name: Recombinant MIP1-alpha Variant ECI301

Label: Recombinant MIP1-alpha Variant ECI301

NCI Thesaurus Code: C98294 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL432412  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
ECI301
eMIP
Recombinant MIP1-alpha Variant ECI301

External Source Codes: 
PDQ Closed Trial Search ID 713863
PDQ Open Trial Search ID 713863 (check for NCI PDQ open clinical trial info)
NCI META CUI CL432412

Other Properties:
     Name Value (qualifiers indented underneath)
code C98294
Contributing_Source CTRP
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C98294

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