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Version: 16.11d (Release date: 2016-11-28)
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SNS01-T Nanoparticles (Code C98288)

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Terms & Properties

Preferred Name: SNS01-T Nanoparticles

Definition: A colloidal mixture of nanoparticles consisting of small interfering RNA (siRNA) targeting the native eukaryotic translation initiation factor 5A (eIF5A), plasmids expressing a pro-apoptotic mutant of elF5A under the control of a B-cell specific promoter (B29), and a synthetic cationic polymer polyethylenimine (PEI) as a delivery vehicle, with potential antineoplastic activity. Upon administration, the siRNA component of SNS01-T suppresses elF5A expression, thereby interfering with translation of eIF5A and reducing levels of hypusinated elF5A in cancer cells. In turn, this inhibits activation of the transcription factor NF-kB and induces apoptosis. In addition, the B-cell specific plasmid component expresses an arginine substituted form of eIF5A, eIF5AK50R, which can not be hypusinated, thus leads to a selective induction of apoptosis in B-cells. The native unhypusinated form of eIF5A is pro-apoptotic and can be modified at the lysine residue, by deoxyhypusine synthase (DHS) and subsequently deoxyhypusine hydroxylase (DHH), to the anti-apoptotic hypusinated form which is associated with tumor cell growth and survival. The delivery vehicle protects the siRNA and plasmid from degradation.

Display Name: SNS01-T Nanoparticles

Label: SNS01-T Nanoparticles

NCI Thesaurus Code: C98288 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL432406  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
SNS01-T
SNS01-T Nanoparticles

External Source Codes: 
PDQ Closed Trial Search ID 712786
PDQ Open Trial Search ID 712786 (check for NCI PDQ open clinical trial info)
NCI META CUI CL432406

Other Properties:
Name Value (qualifiers indented underneath)
code C98288
Contributing_Source CTRP
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C98288

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