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Version: 16.11d (Release date: 2016-11-28)
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GM-CSF-encoding Oncolytic Adenovirus CGTG-102 (Code C98287)

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Terms & Properties

Preferred Name: GM-CSF-encoding Oncolytic Adenovirus CGTG-102

Definition: A recombinant, oncolytic serotype 5/3 capsid-modified adenovirus encoding the immunostimulatory cytokine granulocyte-macrophage colony-stimulating factor (GM-CSF) with potential antineoplastic activity. Upon administration, the oncolytic adenovirus selectively infects and replicates in tumor cells, which may result in tumor cell lysis. Synergistically, GM-CSF (sargramostim) expressed by the oncolytic adenovirus enhances antigen presentation, promotes natural killer (NK) cell-mediated killing and causes a cytotoxic T cell (CTL) response against tumor cells harboring the oncolytic adenovirus, resulting in an immune-mediated tumor cell death. CGTG-102 is designed to replicate only in cells with defects in the p16/Rb/E2F pathway, attributed to a mutation common in many solid tumors. Replacement of the Ad5 capsid protein knob with a knob domain from serotype 3 causes higher transduction in cancer cells as compared to normal cells.

Label: GM-CSF-encoding Oncolytic Adenovirus CGTG-102

NCI Thesaurus Code: C98287 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL432405  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
CGTG-102
GM-CSF-encoding Oncolytic Adenovirus CGTG-102

External Source Codes: 
PDQ Closed Trial Search ID 712555
PDQ Open Trial Search ID 712555 (check for NCI PDQ open clinical trial info)
NCI META CUI CL432405

Other Properties:
Name Value (qualifiers indented underneath)
code C98287
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C98287

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