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Version: 17.06d (Release date: 2017-06-26)
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Allogeneic GM-CSF-secreting Lethally Irradiated Whole Melanoma Cell Vaccine (Code C98282)

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Terms & Properties

Preferred Name: Allogeneic GM-CSF-secreting Lethally Irradiated Whole Melanoma Cell Vaccine

Definition: An allogeneic cancer vaccine composed of lethally irradiated whole melanoma cancer cells that are genetically modified to secrete the immunostimulatory cytokine granulocyte-macrophage colony-stimulating factor (GM-CSF), with potential immunostimulating and antineoplastic activities. Upon intradermal injections, allogeneic GM-CSF-secreting lethally irradiated whole melanoma cell vaccine secretes GM-CSF. In turn, GM-CSF may stimulate the body's immune system against tumor cells by enhancing the activation of dendritic cells (DCs) and promoting antigen presentation to both B- and T-lymphocytes. In addition, GM-CSF promotes antibody-dependent cellular cytotoxicity (ADCC), and increases interleukin-2-mediated lymphokine-activated killer cell function.

Display Name: Allogeneic GM-CSF-secreting Lethally Irradiated Whole Melanoma Cell Vaccine

Label: Allogeneic GM-CSF-secreting Lethally Irradiated Whole Melanoma Cell Vaccine

NCI Thesaurus Code: C98282 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL432401  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Allogeneic GM-CSF-secreting Lethally Irradiated Whole Melanoma Cell Vaccine
GVAX Melanoma Vaccine

External Source Codes: 
PDQ Closed Trial Search ID 712484
PDQ Open Trial Search ID 712484 (check for NCI PDQ open clinical trial info)
NCI META CUI CL432401

Other Properties:
     Name Value (qualifiers indented underneath)
code C98282
Contributing_Source CTRP
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C98282

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