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Version: 16.11d (Release date: 2016-11-28)
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CCL21-expressing H1944 Cell Vaccine (Code C98281)

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Terms & Properties

Preferred Name: CCL21-expressing H1944 Cell Vaccine

Definition: A cancer cell vaccine comprised of the allogeneic human lung adenocarcinoma cell line H1944 that has been transduced ex vivo with adenoviral vector encoding human cytokine chemokine C-C motif ligand 21 (CCL21), with potential immunomodulating and antineoplastic activities. Upon administration, CCL21-expressing H1944 cell vaccine expresses the chemokine CCL21, which may induce an antitumoral cytotoxic T-lymphocyte immune response in the tumor microenvironment. CCL21 has been shown to attract antigen presenting cells (APCs), like leukocytes and DCs, and natural killer (NK) cells and their T-cell effectors to induce a cytotoxic immune response. H1944 cells contain tumor-associated antigens (TAAs) overexpressed in non-small cell lung cancer (NSCLC).

Display Name: CCL21-expressing H1944 Cell Vaccine

Label: CCL21-expressing H1944 Cell Vaccine

NCI Thesaurus Code: C98281 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL432400  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
CCL21-expressing H1944 Cell Vaccine
Recombinant Human 6C Cytokine-expressing H1944 Cell Vaccine

External Source Codes: 
PDQ Closed Trial Search ID 712206
PDQ Open Trial Search ID 712206 (check for NCI PDQ open clinical trial info)
NCI META CUI CL432400

Other Properties:
Name Value (qualifiers indented underneath)
code C98281
Contributing_Source CTRP
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C98281

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